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Article

A novel rat model of hereditary hemochromatosis due to a mutation in transferrin receptor 2.

Comparative medicine - 1 Apr 2013

Bartnikas Thomas B, Wildt Sheryl J, Wineinger Amy E, Schmitz-Abe Klaus, Markianos Kyriacos, Cooper Dale M, Fleming Mark D

Abstract excerpt

Sporadic iron overload in rats has been reported, but whether it is due to genetic or environmental causes is unknown. In the current study, phenotypic analysis of Hsd:HHCL Wistar rats revealed a low incidence of histologically detected liver iron overload. Here we characterized the pathophysiology of the iron overload and showed that the phenotype is heritable and due to a mutation in a single gene. We...

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PMID: 23582421
PMCID: PMC3625055

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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