Article
The chianti zebrafish mutant provides a model for erythroid-specific disruption of transferrin receptor 1.
Development (Cambridge, England) - 1 Dec 2004
Wingert Rebecca A, Brownlie Alison, Galloway Jenna L, Dooley Kimberly, Fraenkel Paula, Axe Jennifer L, Davidson Alan J, Barut Bruce, Noriega Laura, Sheng Xiaoming, Zhou Yi, Zon Leonard I
Abstract excerpt
Iron is a crucial metal for normal development, being required for the production of heme, which is incorporated into cytochromes and hemoglobin. The zebrafish chianti (cia) mutant manifests a hypochromic, microcytic anemia after the onset of embryonic circulation, indicative of a perturbation in red blood cell hemoglobin production. We show that cia encodes tfr1a, which is specifically expressed in the...
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