Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Generation and Characterization of an Abcc1 Humanized Mouse Model (hABCC1) with Knockout Capability

12 Jun 2019

Abstract excerpt

ATP-binding cassette (ABC) transporters such as ABCB1 (P-glycoprotein), ABCC1 (MRP1), and ABCG2 (BCRP) are well known for their role in rendering cancer cells resistant to chemotherapy. Additionally, recent research provided evidence that, along with other ABC transporters (ABCA1 and ABCA7), they might be cornerstones to tackle neurodegenerative diseases. Overcoming chemoresistance in cancer, understanding...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Enzymes and Metabolism
Share to Drug Transport and Resistance Mechanisms
Share to Pharmacological Effects and Toxicity Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31189668
DOI: 10.1124/mol.119.115824

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Generation and Characterization of an Abcc1 Humanized Mouse Model (hABCC1) with Knockout CapabilityPMID 31189668Read ↗

The human ATP‐binding cassette (ABC) transporter superfamilySemantic proximity Read ↗

Mouse ATP-Binding Cassette (ABC) Transporters Conferring Multi-Drug ResistanceSemantic proximity Read ↗

Generation and Characterization of a Novel Multidrug Resistance Protein 2 Humanized Mouse LineSemantic proximity Read ↗

Generation and characterization of a zebrafish knockout model of abcb4, a homolog of the human multidrug efflux transporter P-glycoproteinSemantic proximity Read ↗

Generation and characterization of a zebrafish knockout model of abcb4, a homolog of the human multidrug efflux transporter P-glycoproteinSemantic proximity Read ↗

Identification and characterization of a mammalian mitochondrial ATP-binding cassette membrane protein.Semantic proximity Read ↗

Characterisation of the roles of ABCB1, ABCC1, ABCC2 and ABCG2 in the transport and pharmacokinetics of actinomycin D in vitro and in vivoSemantic proximity Read ↗

A comparison between genetically humanized and chimeric liver humanized mouse models for studies in drug metabolism and toxicitySemantic proximity Read ↗

Generation of 'humanized' hCYP1A1_1A2_Cyp1a1/1a2(-/-) mouse line.Semantic proximity Read ↗

Abcc4 Together with Abcb1 and Abcg2 Form a Robust Cooperative Drug Efflux System That Restricts the Brain Entry of Camptothecin AnaloguesSemantic proximity Read ↗

Application of Chimeric Mice with Humanized Liver for Study of Human-Specific Drug MetabolismSemantic proximity Read ↗

Generation and Characterization of Novel Cytochrome P450 Cyp2c Gene Cluster Knockout and CYP2C9 Humanized Mouse LinesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.