Article

Non-coding RNAs Associated with Prader-Willi Syndrome Regulate Transcription of Neurodevelopmental Genes in Human Induced Pluripotent Stem Cells

2021-05-11

Abstract excerpt

<h4>ABSTRACT</h4> Mutations and aberrant gene expression during cellular differentiation lead to neurodevelopmental disorders such as Prader-Willi syndrome (PWS) which results from the deletion of an imprinted locus on chromosome 15. We analysed chromatin-associated RNA in human induced pluripotent cells (iPSCs) upon depletion of hybrid small nucleolar long non-coding RNAs (sno-lncRNAs) and 5’ snoRNA capped and p...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 219cadf5-9e12-52d0-8d45-179a094f95e3
DOI: 10.1101/2021.05.11.443612

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Non-coding RNAs Associated with Prader-Willi Syndrome Regulate Transcription of Neurodevelopmental Genes in Human Induced Pluripotent Stem CellsDOI 10.1101/2021.05.11.443612Read

Identifying key underlying regulatory networks and predicting targets of orphan C/D box <i>SNORD116</i> snoRNAs in Prader-Willi syndromeSemantic proximity Read

Activation of the imprinted Prader-Willi Syndrome locus by CRISPR-based epigenome editingSemantic proximity Read

Activation of the imprinted Prader-Willi syndrome locus by CRISPR-based epigenome editingSemantic proximity Read

Imprinted expression of UBE3A in non-neuronal cells from a Prader–Willi syndrome patient with an atypical deletionSemantic proximity Read

Roles of SNORD115 and SNORD116 ncRNA clusters in neuronal differentiationSemantic proximity Read

Small molecule inhibitors of G9a reactivate the maternal PWS genes in Prader-Willi-Syndrome patient derived neural stem cells and differentiated neuronsSemantic proximity Read

Maternal transcription of non-protein coding RNAs from the PWS-critical region rescues growth retardation in mice.Semantic proximity Read

Induced Pluripotent Stem Cells Can Be Used to Model the Genomic Imprinting Disorder Prader-Willi SyndromeSemantic proximity Read

Induced pluripotent stem cell models of the genomic imprinting disorders Angelman and Prader–Willi syndromesSemantic proximity Read

Generation of isogenic models of Angelman syndrome and Prader-Willi syndrome in CRISPR/Cas9-engineered human embryonic stem cellsSemantic proximity Read

Integration of CTCF Loops, Methylome, and Transcriptome in Differentiating LUHMES as a Model for Imprinting Dynamics of the 15q11-q13 Locus in Human NeuronsSemantic proximity Read