Article

Analysis of Microsatellite Instability Intensity in Single-Cell Resolution with scMnT reveals Tumor Heterogeneity in Colorectal Cancer

2025-05-14

Abstract excerpt

Although microsatellite instability (MSI) is traditionally regarded as a binary trait, growing evidence indicates that it exists on a continuum, with higher intensity of MSI correlating with better prognosis. However, accurate quantification of MSI intensity is challenging due to the heterogeneous cellular composition of the tumor microenvironment. To this end, we introduce scMnT, a bioinformatic method for identi...

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Literature Corpus work: b986cd84-0dd7-57eb-b4cd-e1e466fb4b64
DOI: 10.1101/2025.05.09.653227

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