Article
Association between somatic microsatellite instability, hypermutation status, and specific T cell subsets in colorectal cancer tumors.
Frontiers in immunology - 1 Jan 2024
Thomas Claire E, Takashima Yasutoshi, Wesselink Evertine, Ugai Tomotaka, Steinfelder Robert S, Buchanan Daniel D, Qu Conghui, Hsu Li, Dias Costa Andressa, Gallinger Steven, Grant Robert C, Huyghe Jeroen R, Thomas Sushma S, Ogino Shuji, Phipps Amanda I, Nowak Jonathan A, Peters Ulrike
Abstract excerpt
Background: Microsatellite instability-high (MSI-high) tumors comprise ~15% of sporadic colorectal cancers (CRC) and are associated with elevated T cell infiltration. However, the universality of this response across T cell subtypes with distinct functions is unknown. Methods: Including 1,236 CRC tumors from three observational studies, we conducted in-situ T cell profiling using a customized 9-plex (CD3, CD4,...
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