Article
Single-cell profiling of the copy-number heterogeneity in colorectal cancer.
Chinese medical journal - 20 Mar 2023
Song Shiyu, Feng Lin, Xi Kexing, Sun Zhigang, Kong Deyang, Luo Zhenkai, Pei Wei, Zhang Haizeng
Abstract excerpt
BACKGROUND: With functionally heterogeneous cells, tumors comprise a complex ecosystem to promote tumor adaptability and evolution under strong selective pressure from the given microenvironment. Diversifying tumor cells or intra-tumor heterogeneity is essential for tumor growth, invasion, and immune evasion. However, no reliable method to classify tumor cell subtypes is yet available. In this study, we...
Topics
- Humans
- Microsatellite Instability
- Ecosystem
- Colorectal Neoplasms
- Prognosis
- Mutation
- Tumor Microenvironment