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Article

Genetic in vivo engineering of human T lymphocytes in mouse models

2020-12-03

Abstract excerpt

<title>Abstract</title> <p>Receptor-targeting of vector particles is a key technology for cell-type specific <italic>in vivo</italic> gene delivery. Lentiviral vectors (LVs) targeted to human T cell markers enable genetic modification of T cells directly in humanized mouse models. Illustrating the example of modifying T cells with chimeric antigen receptors (CARs), we provide detailed protocols for the generation...

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Identifiers and source

Literature Corpus work
b97b5dab-9754-51dd-a1e2-91062acde938
DOI
10.21203/rs.3.pex-1282/v1
Open publication

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Genetic in vivo engineering of human T lymphocytes in mouse modelsDOI 10.21203/rs.3.pex-1282/v1
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