Article
Recent advances in lentiviral vector development and applications.
Molecular therapy : the journal of the American Society of Gene Therapy - 1 Mar 2010
Mátrai Janka, Chuah Marinee K L, VandenDriessche Thierry
Abstract excerpt
Lentiviral vectors (LVs) have emerged as potent and versatile vectors for ex vivo or in vivo gene transfer into dividing and nondividing cells. Robust phenotypic correction of diseases in mouse models has been achieved paving the way toward the first clinical trials. LVs can deliver genes ex vivo into bona fide stem cells, particularly hematopoietic stem cells, allowing for stable transgene expression upon...
Topics
- Animals
- Gene Transfer Techniques
- Genetic Therapy
- Genetic Vectors
- Hematopoietic Stem Cells
- Humans
- Lentivirus
- Ligands
- Models, Genetic
- Mutagenesis
- Phenotype