Article

Regulation of angiogenesis by endocytic trafficking mediated by cytoplasmic dynein 1 light intermediate chain 1

2024-04-01

Abstract excerpt

<h4>ABSTRACT</h4> Dynein cytoplasmic 1 light intermediate chain 1 (LIC1, DYNC1LI1 ) is a core subunit of the dynein motor complex. The LIC1 subunit also interacts with various cargo adaptors to regulate Rab-mediated endosomal recycling and lysosomal degradation. Defects in this gene are predicted to alter dynein motor function, Rab binding capabilities, and cytoplasmic cargo trafficking. Here, we have identified...

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Literature Corpus work: b977ee16-b3ef-50a0-a19a-380f859b6355
DOI: 10.1101/2024.04.01.587559

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