Article
Constitutive Activation of mTORC1 in Endothelial Cells Leads to the Development and Progression of Lymphangiosarcoma through VEGF Autocrine Signaling.
Cancer cell - 14 Dec 2015
Sun Shaogang, Chen Song, Liu Fei, Wu Haige, McHugh Jonathan, Bergin Ingrid L, Gupta Anita, Adams Denise, Guan Jun-Lin
Abstract excerpt
Angiosarcoma/lymphangiosarcoma is a rare malignancy with poor prognosis. We generated a mouse model with inducible endothelial-cell-specific deletion of Tsc1 to examine mTORC1 signaling in lymphangiosarcoma. Tsc1 loss increased retinal angiogenesis in neonates and led to endothelial proliferative lesions from vascular malformations to vascular tumors in adult mice. Sustained mTORC1 signaling was required for...
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