Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Blockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation.

Nature communications - 8 Jun 2020

Martinez-Corral Ines, Zhang Yan, Petkova Milena, Ortsäter Henrik, Sjöberg Sofie, Castillo Sandra D, Brouillard Pascal, Libbrecht Louis, Saur Dieter, Graupera Mariona, Alitalo Kari, Boon Laurence, Vikkula Miikka, Mäkinen Taija

Abstract excerpt

Lymphatic malformations (LMs) are debilitating vascular anomalies presenting with large cysts (macrocystic) or lesions that infiltrate tissues (microcystic). Cellular mechanisms underlying LM pathology are poorly understood. Here we show that the somatic PIK3CAH1047R mutation, resulting in constitutive activation of the p110α PI3K, underlies both macrocystic and microcystic LMs in human. Using a mouse model of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinogenesis
Share to Class I Phosphatidylinositol 3-Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endothelial Cells

Share to Enzyme Activation

Share to Lymphatic Vessels

Share to TOR Serine-Threonine Kinases

Share to Vascular Endothelial Growth Factor C

Share to Vascular Endothelial Growth Factor Receptor-3

Source

Open in PubMed Open full text

Identifiers

PMID: 32513927
DOI: 10.1038/s41467-020-16496-y
PMCID: PMC7280302

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Blockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation.PMID 32513927Read ↗

Constitutively active PIK3CA mutations are expressed by lymphatic and vascular endothelial cells in capillary lymphatic venous malformation.Semantic proximity Read ↗

PIK3CA mutations are specifically localized to lymphatic endothelial cells of lymphatic malformations.Semantic proximity Read ↗

AKT hyper-phosphorylation associated with PI3K mutations in lymphatic endothelial cells from a patient with lymphatic malformation.Semantic proximity Read ↗

Immunoregulatory subtype of dermal lymphatic endothelial cells at capillary terminals drives lymphatic malformationsSemantic proximity Read ↗

Somatic activating mutations in PIK3CA cause generalized lymphatic anomalySemantic proximity Read ↗

A somatic mutation in PIK3CD unravels a novel candidate gene for lymphatic malformation.Semantic proximity Read ↗

Organ‐specific lymphangiectasia, arrested lymphatic sprouting, and maturation defects resulting from gene‐targeting of the PI3K regulatory isoforms p85α, p55α, and p50αSemantic proximity Read ↗

PI3K/mTOR inhibition promotes the regression of experimental vascular malformations driven by PIK3CA-activating mutations.Semantic proximity Read ↗

Map3k3 I441M Knock-In Mouse Model of Cerebral Cavernous MalformationsSemantic proximity Read ↗

Embryological cellular origins and hypoxia-mediated mechanisms in PIK3CA-driven refractory vascular malformationsSemantic proximity Read ↗

Somatic activating mutations in Pik3ca cause sporadic venous malformations in mice and humans.Semantic proximity Read ↗

PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.