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Article

Protein kinase LKB1 promotes RAB7-mediated neuropilin-1 degradation to inhibit angiogenesis.

The Journal of clinical investigation - 1 Oct 2014

Okon Imoh S, Coughlan Kathleen A, Zhang Cheng, Moriasi Cate, Ding Ye, Song Ping, Zhang Wencheng, Li Guangpu, Zou Ming-Hui

Abstract excerpt

After internalization, transmembrane receptors (TMRs) are typically recycled back to the cell surface or targeted for degradation. Efficient TMR trafficking is critical for regulation of several processes, including signal transduction pathways, development, and disease. Here, we determined that trafficking of the angiogenic receptor neuropilin-1 (NRP-1) is abrogated by the liver kinase B1 (LKB1), a...

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Identifiers

PMID: 25180605
DOI: 10.1172/JCI75371
PMCID: PMC4191012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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