Article

<i>Dlc1</i> controls cardio-vascular development downstream of Vegfa/Kdrl/Nrp1 signaling in the zebrafish embryo

2021-02-11

Abstract excerpt

<h4>ABSTRACT</h4> The family of deleted-in-liver-cancer (dlc) genes encodes RhoGTPases and plays pivotal roles in cardiovascular development, but animal models for studying their functions are sparse due to early embryonic lethality. Gain and loss of function of dlc1 and dlc3 severely altered the growth of intersegmental vessels in the trunk of zebrafish embryos. Additionally, overexpression of dlc1 affected...

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Literature Corpus work: 84486b40-43d4-56a1-ad2d-bcb98b0c104b
DOI: 10.1101/2021.02.11.430763

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