Article

Medial temporal lobe Tau-Neurodegeneration <i>mismatch</i> from MRI and plasma biomarkers identifies vulnerable and resilient phenotypes with AD

2025-08-19

Abstract excerpt

While tau pathology is closely associated with neurodegeneration in Alzheimer’s disease (AD), our prior work using multi-modality imaging revealed that mismatch between tau (T) and neurodegeneration (N) may reflect contributions from non-AD processes. The medial temporal lobe (MTL), an early site of AD pathology, is also a common target of co-pathologies such as limbic-predominant age-related TDP-43 encephalopathy...

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Literature Corpus work: b96dd6de-172f-51d7-ba74-700976d544f8
DOI: 10.1101/2025.08.17.25333859

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