Article

Multimodal axes reveal individualized amyloid-β, tau, and neurodegeneration coupling in aging and Alzheimer’s disease

2026-05-26

Abstract excerpt

Can we decode Alzheimer’s disease (AD) heterogeneity into a few portable axes that capture how amyloid-β, tau and neurodegeneration (A-T-N) spatially co vary in vivo? To answer this question, we built a pipeline that harmonizes longitudinal amyloid-β/tau PET and T1 MRI (gray matter) from ADNI cohort (12,430 images) with mixed effects modeling and then derived stage specific multimodal axes (mVCs) using linked comp...

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Literature Corpus work: f850e50c-4f14-59d7-8536-2f4a52f2d325
DOI: 10.64898/2026.05.24.26353955

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