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Alzheimer’s Disease-Like Brain Pattern Biomarker: Capturing Risks and Predicting Disease Onset

2025-09-15

Abstract excerpt

<title>Abstract</title> <p>Preventing Alzheimer’s disease (AD) requires early-warning biomarkers. We developed a Regional Vulnerability Index (RVI) that quantifies individual brain similarity to AD patients' expected brain deficit patterns. We calculated regional effect sizes to establish brain deficit patterns in amyloid-positive AD cases compared to amyloid-negative healthy controls. The RVI-AD was calculated a...

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Literature Corpus work: 1bc128cb-06d2-5e70-b653-3097f5f38302
DOI: 10.21203/rs.3.rs-6770628/v1

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