Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alzheimer's disease-like brain pattern biomarker: capturing risks and predicting disease onset.

Molecular psychiatry - 1 Sept 2026

Kochunov Peter, Gao Si, Salminen Lauren E, Jahanshad Neda, Nir Talia M, Thompson Paul M, Du Xiaoming, Adhikari Bhim M, Kochunov Alice, Cassidy Ryan, Ma Yizhou, Chiappelli Joshua, Ament Seth, Pan Yezhi, Chen Shuo, Shuldiner Alan R, Mitchell Braxton D, Soares L Jair, Hong L Elliot

Abstract excerpt

Preventing Alzheimer's disease (AD) requires early-warning biomarkers. We developed a Regional Vulnerability Index (RVI) that quantifies individual brain similarity to AD patients' expected brain deficit patterns. We calculated regional effect sizes to establish brain deficit patterns in amyloid-positive AD cases compared to amyloid-negative healthy controls. RVI-AD was calculated as a linear index of individual...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Apolipoprotein E4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Apolipoproteins E

Share to Cognitive Dysfunction

Share to Disease Progression

Share to Magnetic Resonance Imaging

Share to Neuroimaging

Share to UK Biobank

Source

Open in PubMed Open full text

Identifiers

PMID: 42045435
DOI: 10.1038/s41380-026-03617-0
PMCID: PMC13441993

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alzheimer's disease-like brain pattern biomarker: capturing risks and predicting disease onset.PMID 42045435Read ↗

Alzheimer’s Disease-Like Brain Pattern Biomarker: Capturing Risks and Predicting Disease OnsetSemantic proximity Read ↗

Genetic, Clinical Underpinnings of Brain Change Along Two Neuroanatomical Dimensions of Clinically-defined Alzheimer’s DiseaseSemantic proximity Read ↗

Towards a multimodal neuroimaging-based risk score for mild cognitive impairment by combining clinical studies with a large (N>37000) population-based studySemantic proximity Read ↗

The Role of Genomic-Informed Risk Assessments in Predicting Dementia OutcomesSemantic proximity Read ↗

Proteomic Signatures of Neuropathological Alterations in Alzheimer’s Disease: Insights from the Bio-Hermes StudySemantic proximity Read ↗

Neuro-Metabolic and Vascular Dysfunction as an Early Diagnostic for Alzheimer’s Disease and Related DementiasSemantic proximity Read ↗

An Integrative Multimodal Model for Early Diagnosis of Dementia and Differential Diagnosis of Alzheimer’s Disease Using Neuroimaging, Polygenic Risk, and Cognitive AssessmentsSemantic proximity Read ↗

Proteomic Signatures of Neuropathological Alterations in Alzheimer’s Disease: Insights from the Bio-Hermes StudySemantic proximity Read ↗

The role of genomic-informed risk assessments in predicting dementia outcomes.Semantic proximity Read ↗

Endophenotype-based polygenic risk scores: Prediction of biomarker and clinical progression and dementiaSemantic proximity Read ↗

Intrinsic Capacity, Polygenic Risk Score, APOE Genotype, and Risk of Dementia: A Prospective Cohort Study Based on the UK Biobank.Semantic proximity Read ↗

Distinct spatiotemporal subtypes of amyloid deposition are associated with diverging disease profiles in cognitively normal and mild cognitive impairment individualsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.