Article
A participant-derived xenograft model of HIV enables long-term evaluation of autologous immunotherapies.
The Journal of experimental medicine - 5 Jul 2021
McCann Chase D, van Dorp Christiaan H, Danesh Ali, Ward Adam R, Dilling Thomas R, Mota Talia M, Zale Elizabeth, Stevenson Eva M, Patel Shabnum, Brumme Chanson J, Dong Winnie, Jones Douglas S, Andresen Thomas L, Walker Bruce D, Brumme Zabrina L, Bollard Catherine M, Perelson Alan S, Irvine Darrell J, Jones R Brad
Abstract excerpt
HIV-specific CD8+ T cells partially control viral replication and delay disease progression, but they rarely provide lasting protection, largely due to immune escape. Here, we show that engrafting mice with memory CD4+ T cells from HIV+ donors uniquely allows for the in vivo evaluation of autologous T cell responses while avoiding graft-versus-host disease and the need for human fetal tissues that limit other...
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