Article

Dnmt1-deficiency in PV interneurons alters cortical circuit function and leads to depression-like behavior

2024-09-29

Abstract excerpt

Neuropsychiatric disorders, including major depressive disorder (MDD), are highly prevalent in modern society, arising from a complex interplay of genetic and environmental factors. Alterations in the function of cortical inhibitory GABAergic interneurons, along with dysregulations of epigenetic signatures and key regulators such as DNA methyltransferase 1 (DNMT1), have been implicated in these conditions. Through...

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Literature Corpus work: fc3d3740-c472-5516-be39-b62f119fe097
DOI: 10.1101/2024.09.28.615593

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