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Article

Engineering Cell-Permeable Proteins through Insertion of Cell-Penetrating Motifs into Surface Loops.

ACS chemical biology - 18 Sept 2020

Chen Kuangyu, Pei Dehua

Abstract excerpt

Effective delivery of proteins into the cytosol of mammalian cells would open the door to a wide range of applications. However, despite great efforts from numerous investigators, effective protein delivery in a clinical setting is yet to be accomplished. Herein we report a potentially general approach to engineering cell-permeable proteins by genetically grafting a short cell-penetrating peptide (CPP) to an...

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Identifiers

PMID: 32786266
DOI: 10.1021/acschembio.0c00593
PMCID: PMC7502474

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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