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Article

Engineering of a Small Protein Scaffold To Recognize Sulfotyrosine with High Specificity.

ACS chemical biology - 20 Aug 2021

Lawrie Justin, Waldrop Sean, Morozov Anya, Niu Wei, Guo Jiantao

Abstract excerpt

Protein tyrosine O-sulfation is an essential post-translational modification required for effective biological processes such as hemostasis, inflammatory response, and visual phototransduction. Because of its unstable nature under mass spectrometry conditions and residing on low-abundance cell surface proteins, sulfated tyrosine (sulfotyrosine) residues are difficult to detect or analyze. Enrichment of...

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Identifiers

PMID: 34251168
DOI: 10.1021/acschembio.1c00382
PMCID: PMC8785239

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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