Article

Controlling TCR and CAR activation by targeting LCK recruitment with a first-in-class small-molecule inhibitor

2025-12-12

Abstract excerpt

T-cell activation is driven by the recruitment of lymphocyte-specific protein tyrosine kinase (LCK) to the T-cell receptor (TCR), a critical step in initiating immune responses. Existing LCK inhibitors lack specificity because they target the conserved kinase domain shared by Src family kinases, resulting in off-target effects. Here, we introduce a novel strategy to selectively modulate T-cell activation by disrup...

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Literature Corpus work: b9284237-bec9-5532-98be-52612e43e4cc
DOI: 10.64898/2025.12.10.693420

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