Article

Modular counterplays shape condensation and signaling of chimeric antigen receptor

2026-07-30

Abstract excerpt

Chimeric antigen receptor-engineered T (CAR T) cell therapy has achieved remarkable clinical efficacy against hematological malignancies but exhibits limited therapeutic outcomes in solid tumors, where immune checkpoint signaling is highly active. Here, we demonstrate that the second-generation CD28-CD3ζ (28Z) CAR undergoes liquid-liquid phase separation with the Src-family kinase LCK to assemble a signaling conde...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b347948a-6b01-5ed2-91a3-23559d87c413
DOI: 10.64898/2026.07.27.741008

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Modular counterplays shape condensation and signaling of chimeric antigen receptorDOI 10.64898/2026.07.27.741008Read

T Cell Activation Machinery: Form and Function in Natural and Engineered Immune ReceptorsSemantic proximity Read

Learning from TCR Signaling and Immunological Synapse Assembly to Build New Chimeric Antigen Receptors (CARs)Semantic proximity Read

Engineering Cytoplasmic Signaling of CD28ζ CARs for Improved Therapeutic FunctionsSemantic proximity Read

Chimeric antigen receptor signaling: Functional consequences and design implicationsSemantic proximity Read

Library-based single-cell analysis of CAR signaling reveals drivers of <i>in vivo</i> persistenceSemantic proximity Read

Building Better Chimeric Antigen Receptors for Adoptive T Cell TherapySemantic proximity Read

Balancing activation and costimulation of CAR tunes signaling dynamics and enhances therapeutic potencySemantic proximity Read

Design and Validation of the First-in-Class PROTACs for Targeted Degradation of the Immune Checkpoint LAG-3Semantic proximity Read

Fine-tuning the CAR spacer improves T-cell potencySemantic proximity Read

An immunoproteomic approach to characterize the CAR interactome and signalosomeSemantic proximity Read

Precise Control of Switchable Chimeric Antigen Receptor T Cells Allows Enhanced Safety and Less T Cell ExhaustionSemantic proximity Read

Cognate Nanovaccine Promotes Tertiary Lymphoid Structures Function and Strengthens Immune Cell Cross-Talk by Targeting Exhausted T Cells in Nonimmunogenic CancersSemantic proximity Read