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Development and characterization of Novel Small Molecule Inhibitors Targeting LAG-3 Protein

2025-08-30

Abstract excerpt

Lymphocyte Activation Gene-3 (LAG-3) is a 503-amino acid transmembrane protein that modulates immune responses by negatively regulating the proliferation and activation of T cells - key effectors in adaptive immunity. The finely tuned expression of LAG-3, along with other immune checkpoints, prevents excessive immune activation and safeguards tissues from inflammation-induced damage. Importantly, the immune system...

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Identifiers and source

Literature Corpus work
a8355385-7fdd-5637-953a-18a9472775dd
DOI
10.1101/2025.08.29.673196
Open publication

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Development and characterization of Novel Small Molecule Inhibitors Targeting LAG-3 ProteinDOI 10.1101/2025.08.29.673196
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