Article

Disease related mutations in PI3Kγ disrupt regulatory C-terminal dynamics and reveals a path to selective inhibitors

2020-12-02

Abstract excerpt

Class I Phosphoinositide 3-kinases (PI3Ks) are master regulators of cellular functions, with the p110 γ subunit playing a key role in immune signalling. PI3K γ is a key factor in inflammatory diseases, and has been identified as a therapeutic target for cancers due to its immunomodulatory role. Using a combined biochemical/biophysical approach, we have revealed insight into regulation of kinase activity, specifi...

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Literature Corpus work: b018f1ae-4c36-521e-810e-fca0b5c09fb4
DOI: 10.1101/2020.12.01.406264

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