Article

Inter-individual variability in immune responses to AAV-mediated ocular gene delivery across species impedes reliable immunomonitoring profile

2025-06-04

Abstract excerpt

<h4>ABSTRACT</h4> Adeno-associated viruses (AAVs) have been used in gene therapy, especially for inherited retinal diseases. Despite their effectiveness in gene transduction, immune responses to the AAV capsid and transgene products have been reported, which can compromise both the efficacy and safety of AAV-mediated therapies. The eye is regarded as an immune-privileged organ where immune activity is constitutiv...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b922d157-16b9-5de9-b04c-9405a0c78748
DOI: 10.1101/2025.06.02.656863

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Inter-individual variability in immune responses to AAV-mediated ocular gene delivery across species impedes reliable immunomonitoring profileDOI 10.1101/2025.06.02.656863Read

Immunology of AAV-Mediated Gene Transfer in the EyeSemantic proximity Read

Humoral immune responses to AAV gene therapy in the ocular compartmentSemantic proximity Read

Systemic and local immune response to intraocular AAV vector administration in non-human primatesSemantic proximity Read

Ocular Inflammatory Response to Intravitreal Injection of Adeno-Associated Virus Vector: Relative Contribution of Genome and CapsidSemantic proximity Read

Risk Mitigation of Immunogenicity: A Key to Personalized Retinal Gene TherapySemantic proximity Read

Human Immune Responses to Adeno-Associated Virus (AAV) VectorsSemantic proximity Read

Understanding and Tackling Immune Responses to Adeno-Associated Viral VectorsSemantic proximity Read

Gene Therapy-Associated Uveitis (GTAU): Understanding and mitigating the adverse immune response in retinal gene therapySemantic proximity Read

Unraveling the Complex Story of Immune Responses to AAV Vectors Trial After TrialSemantic proximity Read

Immunogenicity of Recombinant Adeno-Associated Virus (AAV) Vectors for Gene TransferSemantic proximity Read

Ocular Gene Therapy: An Overview of Viral Vectors, Immune Responses, and Future DirectionsSemantic proximity Read

Adeno-Associated Virus (AAV) Versus Immune ResponseSemantic proximity Read