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Article

Risk Mitigation of Immunogenicity: A Key to Personalized Retinal Gene Therapy

26 Nov 2021

Abstract excerpt

Gene therapy (GT) for ocular disorders has advanced the most among adeno-associated virus (AAV)-mediated therapies, with one product already approved in the market. The bank of retinal gene mutations carefully compiled over 30 years, the small retinal surface that does not require high clinical vector stocks, and the relatively immune-privileged environment of the eye explain such success. However, adverse...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34884622
DOI: 10.3390/ijms222312818

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