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Article

Immunology of AAV-Mediated Gene Transfer in the Eye

1 Jan 2013

Abstract excerpt

The eye has been at the forefront of translational gene therapy largely owing to suitable disease targets, anatomic accessibility, and well-studied immunologic privilege. These advantages have fostered research culminating in several clinical trials and adeno-associated virus (AAV) has emerged as the vector of choice for many ocular therapies. Pre-clinical and clinical investigations have assessed the humoral and...

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PMID: 24009613
DOI: 10.3389/fimmu.2013.00261

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