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Article

Humoral immune responses to AAV gene therapy in the ocular compartment

9 Apr 2021

Abstract excerpt

Viral vectors can be utilised to deliver therapeutic genes to diseased cells. Adeno-associated virus (AAV) is a commonly used viral vector that is favoured for its ability to infect a wide range of tissues whilst displaying limited toxicity and immunogenicity. Most humans harbour anti-AAV neutralising antibodies (NAbs) due to subclinical infections by wild-type virus during infancy and these pre-existing NAbs can...

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PMID: 33837614
DOI: 10.1111/brv.12718

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