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Immunogenicity of Recombinant Adeno-Associated Virus (AAV) Vectors for Gene Transfer

2 Mar 2023

Abstract excerpt

Recombinant adeno-associated viruses (AAVs) have emerged as promising gene delivery vehicles resulting in three US Food and Drug Administration (FDA) and one European Medicines Agency (EMA)-approved AAV-based gene therapies. Despite being a leading platform for therapeutic gene transfer in several clinical trials, host immune responses against the AAV vector and transgene have hampered their widespread...

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PMID: 36862289
DOI: 10.1007/s40259-023-00585-7

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