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Article

Human Immune Responses to Adeno-Associated Virus (AAV) Vectors

17 Apr 2020

Abstract excerpt

Recombinant adeno-associated virus (rAAV) vectors are one of the most promising in vivo gene delivery tools. Several features make rAAV vectors an ideal platform for gene transfer. However, the high homology with the parental wild-type virus, which often infects humans, poses limitations in terms of immune responses associated with this vector platform. Both humoral and cell-mediated immunity to wild-type AAV...

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PMID: 32362898
DOI: 10.3389/fimmu.2020.00670

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