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Adeno-Associated Virus (AAV) Versus Immune Response

25 Jan 2019

Abstract excerpt

Decades ago, Friedmann and Roblin postulated several barriers to gene therapy, including tissue targeting, delivery across the blood⁻brain barrier (BBB), and host immune responses. These issues remain pertinent till today. Since then, several advances have been made in elucidating structures of adeno-associated virus (AAV) serotypes, antibody epitopes, and ways to modify antibody-binding sites. AAVs capsid has...

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PMID: 30691064
DOI: 10.3390/v11020102

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