Article

Systemic and local immune response to intraocular AAV vector administration in non-human primates

2021-09-13

Abstract excerpt

<h4>ABSTRACT</h4> The positive clinical outcomes in adeno-associated virus (AAV)-mediated retinal gene therapy have often been attributed to the low immunogenicity of AAVs along with the immune-privilege of the eye. However, several recent preclinical studies and clinical trials have shown potential for inflammatory responses to AAV mediated gene therapy. Our current understanding of the factors contributing to i...

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Literature Corpus work: 0b48fd8a-c4b5-5544-962c-7160a55973a6
DOI: 10.1101/2021.09.13.460058

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