Article

Ubiquitin-specific peptidase 22 controls integrin-dependent cancer cell stemness and metastasis

2023-06-16

Abstract excerpt

<title>Abstract</title> <p>Integrins plays critical roles in connecting the extracellular matrix and actin skeleton for cell adhesion, migration, signal transduction, and gene transcription, which upregulation is involved in cancer stemness and metastasis. However, the molecular mechanisms underlying how integrins are upregulated in cancer stem cells (CSCs) remain as a biomedical mystery. Herein, we show that the...

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Literature Corpus work: b91f1aff-f09c-5f2d-bbf2-6ede7f420780
DOI: 10.21203/rs.3.rs-2922367/v1

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