Ubiquitin-specific peptidase 22 controls integrin-dependent cancer cell stemness and metastasis

Abstract excerpt

Integrins play critical roles in connecting the extracellular matrix and actin. While the upregulation of integrins is thought to promote cancer stemness and metastasis, the mechanisms underlying their upregulation in cancer stem cells (CSCs) remain poorly understood. Herein, we show that USP22 is essential in maintaining breast cancer cell stemness by promoting the transcription of integrin β1 ( ITGB1 ). Both...

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