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Article

USP22 promotes HER2-driven mammary carcinoma aggressiveness by suppressing the unfolded protein response

18 May 2021

Abstract excerpt

Abstract The Ubiquitin-Specific Protease 22 (USP22) is a deubiquitinating subunit of the mammalian SAGA transcriptional co-activating complex. USP22 was identified as a member of the so-called “death-from-cancer” signature predicting therapy failure in cancer patients. However, the importance and functional role of USP22 in different types and subtypes of cancer remain largely unknown. In the present study, we...

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PMID: 34007022
DOI: 10.1038/s41388-021-01814-5

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