Article

USP22 promotes tumorigenesis and progression by a FKBP12/mTORC1/autophagy positive feedback loop in hepatocellular carcinoma

2023-06-01

Abstract excerpt

<h4>Background: </h4> Ubiquitin-specific protease 22 (USP22) was a potential cancer stem cell (CSC) marker and could promote hepatocellular carcinoma (HCC) stemness upon tumor protein P53 (TP53) inactivation, which have been viewed as drivers of tumorigenesis. Here, we determined the role of USP22 in hepatotumorigenesis, illustrated the underlying mechanism as well as explored the therapeutic significance of USP22...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7e18d666-0f8f-57f5-8391-b12506dcc794
DOI: 10.21203/rs.3.rs-2996323/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

USP22 promotes tumorigenesis and progression by a FKBP12/mTORC1/autophagy positive feedback loop in hepatocellular carcinomaDOI 10.21203/rs.3.rs-2996323/v1Read

Ubiquitin-specific protease 11 serves as a marker of poor prognosis and promotes metastasis in hepatocellular carcinomaSemantic proximity Read

Spotlights on ubiquitin-specific protease 12 (USP12) in diseases: from multifaceted roles to pathophysiological mechanismsSemantic proximity Read

USP14 exhibits high expression levels in hepatocellular carcinoma and plays a crucial role in promoting the growth of liver cancer cells through the HK2/AKT/P62 axisSemantic proximity Read

Operative ubiquitin-specific protease 22 deubiquitination confers a more invasive phenotype to cholangiocarcinoma.Semantic proximity Read

Ubiquitin-specific peptidase 10, a deubiquitinating enzyme: Assessing its role in tumor prognosis and immune responseSemantic proximity Read

Gene Signature and Prognostic Value of Ubiquitin-Specific Proteases Members in Hepatocellular Carcinoma and Explored the Immunological Role of USP36Semantic proximity Read

Deubiquitinating enzyme USP44 suppresses hepatocellular carcinoma progression through inhibiting Hedgehog signaling and PDL1 expressionSemantic proximity Read

Ubiquitin-Specific Peptidase 22 Contributes to Colorectal Cancer Stemness and Chemoresistance via Wnt/β-Catenin PathwaySemantic proximity Read

The deubiquitinase USP21 stabilizes MEK2 to promote tumor growthSemantic proximity Read

USP8 regulates liver cancer progression via the inhibition of TRAF6-mediated signal for NF-κB activation and autophagy induction by TLR4Semantic proximity Read

USP8 promotes the tumorigenesis of intrahepatic cholangiocarcinoma via stabilizing OGTSemantic proximity Read

USP53 plays an antitumor role in hepatocellular carcinoma through deubiquitination of cytochrome cSemantic proximity Read