Mutation in the C-di-AMP cyclase dacA affects fitness and resistance of methicillin resistant Staphylococcus aureus.

doi:10.1371/journal.pone.0073512

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Article

Mutation in the C-di-AMP cyclase dacA affects fitness and resistance of methicillin resistant Staphylococcus aureus.

PloS one - 1 Jan 2013

Dengler Vanina, McCallum Nadine, Kiefer Patrick, Christen Philipp, Patrignani Andrea, Vorholt Julia A, Berger-Bächi Brigitte, Senn Maria M

Abstract excerpt

Faster growing and more virulent strains of methicillin resistant Staphylococcus aureus (MRSA) are increasingly displacing highly resistant MRSA. Elevated fitness in these MRSA is often accompanied by decreased and heterogeneous levels of methicillin resistance; however, the mechanisms for this phenomenon are not yet fully understood. Whole genome sequencing was used to investigate the genetic basis of this...

Topics

Bacterial Proteins
Drug Resistance, Bacterial
Methicillin-Resistant Staphylococcus aureus
Mutation
Phosphorus-Oxygen Lyases

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Identifiers

PMID: 24013956
DOI: 10.1371/journal.pone.0073512
PMCID: PMC3754961

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