Article

Computational design and evaluation of optimal bait sets for scalable proximity proteomics

2024-10-04

Abstract excerpt

The spatial organization of proteins in eukaryotic cells can be explored by identifying nearby proteins using proximity-dependent biotinylation approaches like BioID. BioID defines the localization of thousands of endogenous proteins in human cells when used on hundreds of bait proteins. However, this high bait number restricts the approach’s usage and gives these datasets limited scalability for context-dependent...

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Literature Corpus work: b8fbd546-caa7-54fd-b7ef-974097d5ff72
DOI: 10.1101/2024.10.03.616533

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