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Beyond <i>BRCA</i> deficiency: Clinical and molecular predictors of survival in patients with <i>BRCA</i>-deficient tubo-ovarian high-grade serous carcinoma

2025-09-22

Abstract excerpt

<h4>ABSTRACT</h4> BRCA -associated homologous recombination deficiency (HRD) is present in ∼50% of high-grade serous carcinomas (HGSC) and predicts sensitivity to platinum-based therapy. However, there is little understanding of why some patients with BRCA -deficient tumors experience unexpectedly poor outcomes. We profiled 154 tumors, enriched for patients with BRCA -deficient tumors that experienced short overa...

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Literature Corpus work
b8f5ad03-4917-516b-a1f8-8e9f02e09b8a
DOI
10.1101/2025.09.17.25335919
Open publication

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Beyond <i>BRCA</i> deficiency: Clinical and molecular predictors of survival in patients with <i>BRCA</i>-deficient tubo-ovarian high-grade serous carcinomaDOI 10.1101/2025.09.17.25335919
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