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RB1 expression and HR proficiency define a poor-outcome molecular subtype of high grade serous ovarian carcinoma

2025-07-14

Abstract excerpt

<title>Abstract</title> <p>High-grade serous ovarian carcinoma (HGSOC) is a molecularly heterogeneous and lethal malignancy, with late-stage diagnosis contributing to high risk of recurrence and poor clinical outcomes. While homologous recombination (HR) deficiency and retinoblastoma gene (<italic>RB1</italic>) expression have been implicated in prognosis, their combined role in shaping tumor biology and survival...

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Literature Corpus work
88290de7-b0d8-5016-876d-5c8d61b8625a
DOI
10.21203/rs.3.rs-5523163/v1
Open publication

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