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Article

Molecular classification of ovarian high-grade serous/endometrioid carcinomas through multi-omics analysis: JGOG3025-TR2 study.

British journal of cancer - 1 Nov 2024

Takamatsu Shiro, Hillman R Tyler, Yoshihara Kosuke, Baba Tsukasa, Shimada Muneaki, Yoshida Hiroshi, Kajiyama Hiroaki, Oda Katsutoshi, Mandai Masaki, Okamoto Aikou, Enomoto Takayuki, Matsumura Noriomi

Abstract excerpt

BACKGROUND: Considerable interobserver variability exists in diagnosis of ovarian high-grade endometrioid carcinoma (HGEC) and high-grade serous carcinoma (HGSC) due to histopathological similarities. While homologous recombination deficiency (HRD) correlates with drug sensitivity in HGSC, the molecular features of HGEC are unclear. METHODS: Fresh-frozen samples from 15 ovarian HGECs and 274 ovarian HGSCs in the...

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Identifiers

PMID: 39215190
DOI: 10.1038/s41416-024-02837-x
PMCID: PMC11473812

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