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Beyond BRCA deficiency: Clinical and molecular predictors of survival in patients with BRCA-deficient tubo-ovarian high-grade serous carcinoma

2025-10-03

Abstract excerpt

<title>Abstract</title> <p><italic>BRCA</italic>-associated homologous recombination deficiency (HRD) is present in ~ 50% of high-grade serous carcinomas (HGSC) and predicts sensitivity to platinum-based therapy. However, there is little understanding of why some patients with <italic>BRCA</italic>-deficient tumors experience unexpectedly poor outcomes. We profiled 154 tumors, enriched for patients with <italic>B...

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Literature Corpus work
0014dbde-4458-53f5-af93-f149d5b9d955
DOI
10.21203/rs.3.rs-7572112/v1
Open publication

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Beyond BRCA deficiency: Clinical and molecular predictors of survival in patients with BRCA-deficient tubo-ovarian high-grade serous carcinomaDOI 10.21203/rs.3.rs-7572112/v1
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