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Concurrent RB1 loss and<i>BRCA</i>-deficiency predicts enhanced immunological response and long-term survival in tubo-ovarian high-grade serous carcinoma

2023-11-10

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Somatic loss of the tumour suppressor RB1 is a common event in tubo-ovarian high-grade serous carcinoma (HGSC), which frequently co-occurs with alterations in homologous recombination DNA repair genes including BRCA1 and BRCA2 ( BRCA ). We examined whether tumour expression of RB1 was associated with survival across ovarian cancer histotypes (HGSC, endometrioid (ENOC), clear c...

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Literature Corpus work
8bcb262a-56cc-52ab-a713-e11d8554fac8
DOI
10.1101/2023.11.09.23298321
Open publication

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Concurrent RB1 loss and<i>BRCA</i>-deficiency predicts enhanced immunological response and long-term survival in tubo-ovarian high-grade serous carcinomaDOI 10.1101/2023.11.09.23298321
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