Homologous recombination deficiency in high-grade serous ovarian carcinoma: clinical pathological characteristics, impact of neoadjuvant chemotherapy, and prognostic implications.

Abstract excerpt

OBJECTIVE: To investigate the clinicopathological and prognostic significance of homologous recombination deficiency (HRD) in high-grade serous ovarian carcinoma (HGSC) and evaluate the impact of neoadjuvant chemotherapy (NACT) on HRD detection. METHODS: HRD status was assessed in 126 surgically resected HGSC samples (30 post-NACT, 96 primary surgery) using the AmoyDx® HRD Complete Panel. HRD positivity was...

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