Article

Proteomics of human cancer-associated T cells identifies regulators of T cell functionality

2026-08-23

Abstract excerpt

CD8 + T cells in solid cancers progressively lose anti-tumor activity, yet the cell-intrinsic mechanisms driving this loss of function remain incompletely defined. Here, we performed matched proteomic and transcriptomic profiling of dysfunctional and bystander CD8 + tumor-infiltrating T cells isolated from primary tumors of treatment-naïve non-small cell lung cancer patients. Proteomic analysis revealed widespre...

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Literature Corpus work: b8f2d9db-66ce-55ba-9a0e-f39245f9d2bd
DOI: 10.64898/2026.08.18.745433

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