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Insights into the involvement of spliceosomal mutations in myelodysplastic disorders from an analysis of SACY-1/DDX41 in <i>Caenorhabditis elegans</i>

2019-12-23

Abstract excerpt

<h4>ABSTRACT</h4> Mutations affecting spliceosomal proteins are frequently found in hematological malignancies, including myelodysplastic syndromes and acute myeloid leukemia. DDX41/Abstrakt is a metazoan-specific spliceosomal DEAD-box RNA helicase found to be recurrently mutated in inherited myelodysplastic syndromes and in relapsing cases of acute myeloid leukemia. The genetic properties and genomic impacts of...

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Literature Corpus work
b8ec54a5-2708-5a74-ae0f-223e96eb6afe
DOI
10.1101/2019.12.23.886804
Open publication

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Insights into the involvement of spliceosomal mutations in myelodysplastic disorders from an analysis of SACY-1/DDX41 in <i>Caenorhabditis elegans</i>DOI 10.1101/2019.12.23.886804
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