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Insights into the Involvement of Spliceosomal Mutations in Myelodysplastic Disorders from Analysis of SACY-1/DDX41 in Caenorhabditis elegans

14 Feb 2020

Abstract excerpt

Abstract Mutations affecting spliceosomal proteins are frequently found in hematological malignancies. DDX41/Abstrakt is a metazoan-specific spliceosomal DEAD-box RNA helicase found to be recurrently mutated in relapsing cases of acute myeloid leukemia, as well as in inherited myelodysplastic syndromes... Mutations affecting spliceosomal proteins are frequently found in hematological malignancies, including...

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PMID: 32060018
DOI: 10.1534/genetics.119.302973

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