Article

Digital color-coded molecular barcoding reveals dysregulation of common FUS and FMRP targets in soma and neurites of ALS mutant motoneurons

2022-08-02

Abstract excerpt

<h4>ABSTRACT</h4> Mutations in RNA binding proteins (RBPs) have been linked to the motor neuron disease amyotrophic lateral sclerosis (ALS). Extensive auto-regulation, cross-regulation, cooperation and competition mechanisms among RBPs are in place to ensure proper expression levels of common targets, often including other RBPs and their own transcripts. Moreover, several RBPs play a crucial role in the nervous s...

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Literature Corpus work: b8dc15b8-5c83-5463-839b-4c7117470f3a
DOI: 10.1101/2022.08.02.502510

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